The mitochondrial DNA genetic bottleneck: inheritance and beyond
نویسندگان
چکیده
منابع مشابه
Mitochondrial DNA Mutations, Pathogenicity and Inheritance
Mitochondria contain their own DNA (mtDNA), which codes for 13 proteins (all subunits of the respiratory chain complexes), 22 tRNAs and 2 rRNAs. Several mtDNA point mutations as well as deletions have been shown to be causative in well-defined mitochondrial disorders. A mixture of mutated and wild type mtDNA (heteroplasmy) is found in most of these disorders. Inheritance of mtDNA is maternal, a...
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The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of heteroplasmy (the presence of several alleles in an individual), yet its transmission across generations cannot be readily predicted owing to a lack of data on the size of the mtDNA bottleneck during oogenesis. For deleterious heteroplasmies, a severe bottleneck may abruptly transform a benign (low) frequency in...
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F or all it has given to science, Mendelian genetics is now a sim-plistic view of inheritance. On top of the DNA code lies another genetic " language, " the epigenetic code. Wolf Reik has built a career of decoding this language. Reik jumped on the now crowded epigenetic bandwagon when it was in its infancy, during both his PhD with Rudolf Jaenisch in Germany and his postdoc with Azim Surani in...
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—The California Condor (Gymnogyps californianus) has recently survived a severe population bottleneck. The entire population was reduced to 27 individuals in 1982. The number of genetic founders was even smaller. We obtained 482 base pairs of DNA sequence from the mitochondrial control region (CR) of all founder individuals that poten tially represented unique maternal haplotypes. Four unique ...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2018
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20170096